FIGURE 3.
Gαz-null mice demonstrate a better maintenance of stimulation of plasma insulin levels, both with age and HFD feeding. A, plasma insulin levels recorded at t = 0 and t = 10 min during the final IP-GTT. The data were analyzed by paired t test to determine the effect of time within a group and by unpaired t test with Welch's correction, which corrects for unequal variances, among treatment groups. B, acute insulin response, which is the plasma insulin after glucose challenge (t = 10 min) as normalized to the plasma insulin levels at t = 0 min. The data were analyzed by unpaired t test. *, p < 0.05; **, p < 0.01; ***, p < 0.001. ctrl, control.