FIGURE 1.

Genetic locus involved in LOS biosynthesis. Genes involved in LOS biosynthesis obtained from our screen are depicted in bold and underlined, with the location of individual mutants indicated below the dark gray arrows. LOS biosynthesis defects were shown previously for gene disruption of mm2309, losA, mm2332, mm2333, and papA4 (15, 16, 18, 20) and deletion of region mm2314 to mm2317 (19) (depicted in light gray as a single responsible gene was not assigned). Similar LOS biosynthesis defects are observed in disruption of adjacent genes or genes in close proximity to each other, suggesting genomic clustering. The defects are explained below the gray arrows.