FIGURE 2.

Accumulation of degenerated mitochondria and SR membranes produce areas of vacuolization. A, in some instances, damaged mitochondria formed large clusters that were located either under the sarcolemma or between myofibrils (open arrows). B–D, mitochondrial degeneration was often associated with SR membrane fragmentation (C, arrows) and with formation of different size vacuoles (asterisks). There were also frequent accumulation of stack-like aggregations of the SR membranes (wavy arrow). Bars, A, 2 μm; B–D, 1 μm.