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. 2012 Apr 19;287(24):20534–20544. doi: 10.1074/jbc.M112.359588

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Accumulation of amorphous materials and membrane bound inclusions. A, regions of the cell characterized by accumulation of degenerating mitochondria and vacuolization (open arrows) also contained accumulations of amorphous electron-dense material (asterisks). B and C, the electron-dense material was granular in appearance and was observed either with (C, arrowhead) or without (C, asterisk) a membrane envelope. In certain MCK-βAPP fibers, stack-like aggregations of the SR membranes were also observed (wavy arrows). Bars, A, 1 μm; B and C, 0.5 μm.