FIGURE 8.

Potential mechanisms for PRK2 dimerization. A, a schematic representation of the active PRK2 monomer. The catalytic domain contains two binding sites for N-terminal domains (binding site 1 and binding site 2, boxed). The N-terminal region contains the PKL linker and additional sites that potentially bind to the catalytic domain. For simplification, the C-terminal extension of PRK2 is not shown and the N-terminal region is minimized. B, a possible model for the dimerization of PRK2 molecules is based on the existence of pre-formed binding sites (binding site 2) already present in the monomer. In this model, the PKL region of one molecule interacts with the dimer partner, whereas the other N-terminal sites interact with both molecules of the dimer.