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The “funky” mutation is a B2 SINE insertion into exon 3 of Ndufs4. A, sequencing chromatograph comparing Ndufs4 exon 3 in wild type and homozygous mice; the inserted sequence begins 52 nt after the 5′ start of the exon. B, RepeatMasker output showing alignment of insert sequence with B2_Mm1a; 171 of 176 nt = 97% match. Transition and transversion substitutions are indicated by i and v, respectively. C, Ndufs4fky locus showing the B2 insert and target site duplication (TSD) sequences.
