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. 2012 Apr 25;287(24):20652–20663. doi: 10.1074/jbc.M111.327601

FIGURE 5.

FIGURE 5.

Schematic representation of the results from nano-LC-MS/MS analysis of the crippled CI in mitochondria from Ndufs4fky/fky mice. Left, the different modules present in CI in wild type mice. Right, crippled complex I from Ndufs4fky/fky mice misses all subunits that make up the N module, whereas the assembly factors Ndufaf1 and Ndufaf2 were found associated with the crippled complex I. Representation of the outcome of nano-LC-MS/MS analysis was based on the assembly model described by McKenzie and Ryan (64).