Table 1.
ROI | Sensitivity | Specificity | PPV |
---|---|---|---|
Tumor rim | 75 ± 13 | 74 ± 10 | 91 ± 4 |
Tumor center | 45 ± 17 | 95 ± 4 | 96 ± 2 |
Normal muscle | 3 ± 8 | 99 ± 1 | 58 ± 16 |
Sensitivity to tumor vasculature is greatest in the tumor rim (P < 0.0004) compared with that of the tumor center of normal muscle. Specificity is less in the tumor rim than in the other two ROIs, but this value indicates the inherent compromise between sensitivity and specificity. Greater sensitivity or specificity could be achieved, but at the expense of the other. Positive predictive value in both tumor ROIs are high. This suggests that when vasculature is present in either the tumor rim or center, HiSS is capable at detecting it.