Figure 16.

The group-pacemaker hypothesis realized in an explicit mathematical model. A) On-cell patch recording in the preBötC with inspiratory motor discharge (XII). Below, whole-cell recording of the same cell as above after rupture of the patch, also with XII output. Baseline membrane potential was −60 mV. B) Data from another preBötC neuron in whole cell recording is plotted with the model behavior. C) Fast sweep of a burst in the model from B (above) coded with numerals to illustrate the sequence of physiological steps in one model burst in the Na⁺-Ca²⁺ phase plane, which is also displayed. Specific captions are superimposed with the circle-enclosed numbers to encapsulate model dynamics in sequence. See text for more detail. These data were modified with permission from Rubin et al. (2009) Proc Natl Acad Sci USA, 106, 2939–44