Table 1.
Enrichment of Genes Altered by NSAIDs in CASMC and HCAEC
| Category | Genes in category | CASMC | HCAEC | ||
|---|---|---|---|---|---|
| # of Genes | p-value | # of Genes | p-value | ||
| Cell cycle | 1143 | 180 | 5.33E-58 | 148 | 3.24E-56 |
| DNA replication | 282 | 60 | 4.66E-27 | 43 | 8.09E-20 |
| DNA repair | 285 | 54 | 5.52E-22 | 42 | 7.92E-19 |
| DNA binding | 3073 | 222 | 7.61E-19 | 173 | 1.98E-19 |
| Response to stress | 1114 | 105 | 1.62E-16 | 67 | 2.52E-09 |
| Cyclin | 152 | 33 | 8.14E-16 | 23 | 3.33E-11 |
| Proliferation | 950 | 90 | 1.79E-14 | 61 | 1.15E-09 |
| Apoptosis | 934 | 75 | 5.05E-09 | 50 | 7.00E-06 |
| DNA damage | 119 | 21 | 7.32E-09 | 15 | 9.64E-07 |
| Signal transduction | 2344 | 139 | 8.74E-07 | 83 | 1.06E-02 |
| Histone | 335 | 32 | 3.84E-06 | 24 | 2.15E-05 |
| Growth factor | 710 | 53 | 7.14E-06 | 26 | 8.36E-02 |
| Transcription factor | 1665 | 99 | 2.93E-05 | 87 | 9.66E-09 |
| Ubiquitin | 682 | 49 | 4.11E-05 | 34 | 6.87E-04 |
| Cytokine | 471 | 37 | 5.71E-05 | 14 | 4.13E-01 |
| Immune response | 865 | 55 | 3.45E-04 | 21 | 7.40E-01 |
| Oncogene | 301 | 24 | 8.62E-04 | 11 | 2.04E-01 |
| Cardiovascular | 1044 | 62 | 8.68E-04 | 39 | 3.27E-02 |
| Interferon | 193 | 16 | 4.00E-03 | 7 | 2.78E-01 |
| Inflammation | 217 | 16 | 1.18E-02 | 7 | 3.83E-01 |
Genes differentially expressed (> 2-fold change, p< 0.05) by CXB, NS and IBU in CASMC and HCAEC were classified into functional categories by gene ontology classification. Enrichment of individual functional gene categories was determined by hypergeometric distribution P values obtained from comparison of the number of genes differentially expressed to the number of annotated genes in each category.