Table 2.

Cell Cycle Perturbations in CASMC and HCAEC Cells Treated with NSAIDs

	CASMC			HCAEC
	G1	S	G2	G1	S	G2
DMSO C	69.3 ± 2.0	18.6 ± 2.1	12.1 ± 0.3	49.1 ± 2.2	25.0 ± 1.0	26.0 ± 0.7
10μM CXB	67.2 ± 0.8	18.4 ± 2.0	14.3 ± 1.4	47.8 ± 4.1	23.6 ± 0.5	28.5 ± 3.1
40μM CXB	73.1 ± 0.4†	6.4 ± 0.4**††	20.5 ± 0.7**††	61.3 ± 1.4*†	13.7 ± 1.6**††	25.0 ± 0.8
DMSO C	69.4 ± 1.3	19.2 ± 1.1	11.5 ± 1.5	47.5 ± 1.6	27.0 ± 1.1	25.5 ± 1.9
10μM NS	65.9 ± 1.1	21.1 ± 1.6	13.0 ± 0.6	45.3 ± 1.0	22.6 ± 1.5	32.2 ± 0.6
100μM NS	68.4 ± 0.7	18.3 ± 1.0	13.3 ± 1.7	44.8 ± 0.6	24.3 ± 1.6	30.9 ± 1.6
H2O C	69.0 ± 1.8	16.4 ± 0.7	13.6 ± 1.4	42.4 ± 1.9	24.8 ± 1.8	32.9 ± 1.8
0.1mM IBU	71.1 ± 2.8	15.1 ± 1.6	13.9 ± 1.2	46.1 ± 2.9	23.7 ± 0.8	30.2 ± 3.0
1.5mM IBU	59.7 ± 2.1*†	24.5 ± 2.5*†	15.9 ± 0.5	58.5 ± 0.9**†	14.4 ± 4.0	27.0 ± 4.0

Cells were treated with CXB (10 & 40 μmol/L), NS (10 & 100 μmol/L) and IBU (0.1 & 1.5 mmol/L) for 24h (HCAEC) or 48h (CASMC) and percentages of cells in G1, S and G2M were determined. Each data point represents mean ± SEM (n=3).

^*Comparison between control and NSAIDs

^*p<0.05,

^**p<0.01

^†Comparison between low and high concentrations of NSAIDs

^†p<0.05,

^††p<0.01