Table 4.

Functions Associated with Networks of Genes Differentially Expressed by NSAIDs in CASMC

Treatment	Network ID	Score	Focus Molecules	Top Functions
10μM CXB	1	22	8	Cell Cycle, Gene Expression, DNA Replication, Recombination, and Repair
10μM NS	1	29	11	Cellular Movement, Cell-To-Cell Signaling and Interaction, Cellular Growth and Proliferation
0.1mM IBU	1	32	12	Antigen Presentation, Cell-To-Cell Signaling and Interaction, Hematological System Development and Function
40μM CXB	1	60	33	Cellular Assembly and Organization, DNA Replication, Recombination, and Repair, Cell Death
	2	43	27	Cell Cycle, Cancer, Skeletal and Muscular Disorders
	3	42	27	Cell Cycle, Cellular Assembly and Organization, Amino Acid Metabolism
	4	40	28	Cell Cycle, Cancer, Genetic Disorder
	5	38	25	Cell Cycle, Cancer, Skeletal and Muscular Disorders
	9	25	19	Infection Mechanism, Antigen Presentation, Cellular Movement
	13	21	18	Cell Cycle, Cellular Movement, Cardiovascular System Development and Function
	16	19	15	Developmental Disorder, Renal and Urological Disease, Free Radical Scavenging
	19	16	13	Cellular Development, Hematological System Development and Function, Hematopoiesis
	20	15	13	Cellular Development, Connective Tissue Development and Function, Inflammatory Response
100μM NS	1	32	15	Cardiovascular System Development and Function, Cell Cycle, Infection Mechanism
	2	20	10	Cellular Growth and Proliferation, Cellular Development, Cell Death
	3	20	10	Organismal Injury and Abnormalities, Cell Death, Cell Morphology
1.5mM IBU	1	41	32	Molecular Transport, RNA Trafficking, DNA Replication, Recombination, and Repair
	2	39	31	Cell Cycle, Cellular Assembly and Organization, DNA Replication, Recombination, and Repair
	3	37	31	Cell Cycle, Cancer, Genetic Disorder
	4	36	30	Drug Metabolism, Cellular Function and Maintenance, Cellular Movement
	5	35	29	DNA Replication, Recombination, and Repair, Cell Cycle, Cancer
	6	33	29	Gastrointestinal Disease, Cardiovascular Disease, Cellular Compromise
	8	31	28	Cancer, Gastrointestinal Disease, Genetic Disorder
	9	31	27	Cancer, Reproductive System Disease, Cardiovascular Disease
	14	28	26	Cardiovascular System Development and Function, Cell-To-Cell Signaling and Interaction, Nervous System Development and Function
	15	27	25	Cell Death, Hematological System Development and Function, Hypersensitivity Response
	21	23	23	Gene Expression, Antimicrobial Response, Inflammatory Response

Ingenuity pathway analysis of differentially expressed genes in CASMC treated with low and high concentrations of celecoxib, NS398 and ibuprofen. The network ID, score, number of focus molecules and the functions associated with top 5 networks with a score >10 are shown. In addition, the networks with score >10 and changes in molecules related to cardiovascular disease, gastrointestinal disease, renal and urological disease, inflammatory and immunological disease are also included. These categories and the hematological and cardiovascular system development and function categories are shown in bold.