Table 5.
Functions Associated with Networks of Genes Differentially Expressed by NSAIDs in HCAEC
| Treatment | Network ID | Score | Focus molecules | Top Functions |
|---|---|---|---|---|
| 10μM CXB | 1 | 32 | 12 | Cell Cycle, Cellular Development, Cellular Assembly and Organization |
| 10μM NS | 1 | 22 | 9 | Gene Expression, Cellular Development, Digestive System Development and Function |
| 0.1mM IBU | 1 | 27 | 10 | Cancer, Gene Expression, Drug Metabolism |
| 40μM CXB | 1 | 46 | 28 | Cell Cycle, Cancer, DNA Replication, Recombination, and Repair |
| 2 | 43 | 27 | Cellular Function and Maintenance, Gene Expression, Cellular Development | |
| 3 | 43 | 28 | Cell Cycle, DNA Replication, Recombination, and Repair, Cellular Growth and Proliferation | |
| 4 | 39 | 28 | Cell Cycle, DNA Replication, Recombination, and Repair, Cellular Assembly and Organization | |
| 5 | 39 | 26 | Cell Cycle, Cellular Movement, DNA Replication, Recombination, and Repair | |
| 9 | 27 | 20 | Hematological System Development and Function, Tissue Morphology, Cellular Development | |
| 12 | 22 | 17 | Cellular Development, Hematological System Development and Function, Hematopoiesis | |
| 16 | 20 | 16 | Infection Mechanism, Antimicrobial Response, Inflammatory Response | |
| 18 | 19 | 17 | Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Antigen Presentation | |
| 100μM NS | 1 | 63 | 26 | Cellular Growth and Proliferation, Tissue Morphology, Cell Cycle |
| 2 | 24 | 13 | Cell Cycle, Cancer, Gastrointestinal Disease | |
| 3 | 21 | 11 | Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking | |
| 1.5mM IBU | 1 | 43 | 32 | Cell Cycle, Cellular Growth and Proliferation, Cardiovascular Disease |
| 2 | 39 | 31 | Cancer, Renal and Urological Disease, DNA Replication, Recombination, and Repair | |
| 3 | 38 | 30 | DNA Replication, Recombination, and Repair, Gene Expression, Cancer | |
| 4 | 37 | 30 | Carbohydrate Metabolism, Lipid Metabolism, Small Molecule Biochemistry | |
| 5 | 36 | 29 | Skeletal and Muscular System Development and Function, Cell Death, Immunological Disease | |
| 6 | 36 | 29 | Infection Mechanism, Cell Morphology, DNA Replication, Recombination, and Repair | |
| 12 | 30 | 26 | Gastrointestinal Disease, Genetic Disorder, Inflammatory Disease | |
| 16 | 26 | 25 | Cardiovascular System Development and Function, Skeletal and Muscular System Development and Function, Tissue Morphology | |
| 18 | 23 | 22 | Cell Cycle, Cancer, Hematological Disease | |
| 19 | 22 | 22 | Gene Expression, Antimicrobial Response, Inflammatory Response | |
| 24 | 18 | 19 | Inflammatory Disease, Ophthalmic Disease, Endocrine System Disorders | |
| 25 | 18 | 19 | Cell-mediated Immune Response, Cellular Movement, Immune Cell Trafficking |
Ingenuity pathway analysis of differentially expressed genes in HCAEC treated with low and high concentrations of celecoxib, NS398 and ibuprofen. In addition to top 5, the networks with score >10 and changes in molecules related to cardiovascular disease, gastrointestinal disease, renal and urological disease, inflammatory and immunological disease are also included. These categories and the hematological and cardiovascular system development and function categories are shown in bold.