Table 6.

Cardiovascular Functions of Genes Differentially Expressed by NSAIDs

FUNCTIONS	GENE SYMBOLS
Inflammation, inflammatory response	RELB, KITLG, LAP (C/EBP), OSMR, THBD, PTX3, CCL20, CCL25,HMGB1, CXCL12, IL16, PRSS23, F2RL1, PLA2G4A, LP-PLA2
Platelet activation	GP1BA,PLA2G4A, FGA, F2R
Chemotaxis, chemo-attraction, adhesion,	CCL20, CCL25,CCL2, DOCK2, CXCL12, IL16,THBS1
Hyperlipidemia	PTGS2, TXNIP, VLDRLCH
Atherosclerotic lesion including fibrosis, growth, thrombosis	PTX3, PTGS2, ERN1,SERPINB8, HRG1, GP1BA, VLDLRCH, THBD,P2RY1,TFPI-2, FGA,, FN1, F2R, F2RL1, PLAT, ACAT2, CCL2, PDE4A, CD59, KPTN, PLA2G4A, LP-PLA2,PLG, THBS1, ANGPT2, PROC
Myocardial ischemia, heart failure	AMY2B, DUSP6, PTGS2, ADRA1B, IGF2R, MDM2, HTT, MYH7, PDE4A, BIRC5, APLN, CTGF, E2F1, NPR3PLG,
Ischemia, ischemic cardiomyopathy	DDIT3, PTGS2, ADORA2B, CXCL3, GP1BA, PPP1R15, NPR3, CXCL12, ENG, HMGB1, PARP1, F2R,PLG,
Myocardial infarction, infarct	CD55, ADORA2B, ADRA1B, IL1A, IRF1, NAMPT, PMAIP1, THBD, CAPN5, PTGS2BAT1, HMGB1, COL3A1, CXCL12, ACTA1, PLG,
Tachycardia, arrhythmia, atrial fibrillation	CHRNA7, CHRNE, KITLG, PTGS2, TAC1, ADORA2B, ADRA1B, UCN, KCNMA1,VCL, HMGB1
Pericarditis	TUBA1A, TUBA4B, TUBB3, TUBB2C, TUBE1
Dilation of heart	CCNA2, LMNA, PTGES, F2R
Cardiac damage, injury	ANXA1, ATF4, HMOX1,APLN
Cardiac necrosis/cell death	MDM2, NAMPT, TXNIP, UCN, GABRD,PARP1, TNFAIP3, BCL2L11, BIRC5, E2F1, FSTL1, ZYX, NRG
Cardiac hypertrophy	ATF3, ADAM17, PTGS2, DUSP1, HDAC9, FBXO32, IER3, MDM2, HMOX1, FABP3,SMTN, BIRC5, CXCL12, PBX1, PLA2G4A, F2R, CTSC, H2AFZ, IL33, NFATC4, PTGES, RGS4, S100A10, TNFAIP3, APLN, DES, MYH7, ANGPT2
Hyperplasia, regeneration	CCNA2, HMGB1
Stroke	FABP3, PTGS2, RRM2, SPATA13

Up-regulated genes are shown in bold and down-regulated genes are shown in italics. The expression pattern of the underlined genes PLG, THBS1, ANGPT2 and PROC was dependent on either the specific drug or the cell type.