Table 2.
Performances of eight serological tests for diagnosis of schistosomiasis
| Testa | Sensitivityd |
Specificityd (n = 104) | Indeterminate resultsc | ||
|---|---|---|---|---|---|
| All casesb (n = 37) | S. mansoni (n = 21) | S. haematobium (n = 14) | |||
| IFAT | 75.7 (58.4–97.6) | 85.7 (62.6–96.2) | 64.3 (35.6–86.0) | 98.1 (92.5–99.7) | 10.7/5.6/22.2 |
| ELISA/CA | 40.5 (25.2–57.8) | 47.6 (26.4–69.7) | 21.4 (5.7–51.2) | 95.2 (88.6–98.2) | 80.0/70.0/100.0 |
| ELISA/AWA | 54.1 (37.1–70.2) | 76.2 (52.4–90.9) | 21.4 (5.7–51.2) | 100 (95.6–100) | 28.6/31.3/25.0 |
| ELISA/SEA | 75.7 (58.4–97.6) | 90.5 (68.2–98.3) | 57.1 (29.6–81.2) | 97.1 (91.2–99.3) | 50.0/52.6/50.0 |
| IHA | 73.0 (55.6–85.6) | 76.2 (52.4–90.9) | 71.4 (42.0–90.4) | 99.0 (94.0–100) | 22.2/0.0/60.0 |
| ELISA/NovaTec | 64.9 (47.4–79.3) | 81.0 (57.4–93.7) | 35.7 (14.0–64.4) | 99.0 (94.0–100) | 16.7/11.8/20.0 |
| ELISA/DRG | 78.3 (61.3–89.6) | 85.7 (62.6–96.2) | 71.4 (42.0–90.4) | 88.4 (80.3–93.6) | NA |
| ELISA/Viramed | 67.6 (50.1–81.4) | 71.4 (47.7–87.8) | 64.3 (35.6–86.0) | 76.9 (67.4–84.4) | NA |
a
For explanations of test abbreviations, see Materials and Methods.
b
Includes two cases of infections with multiple Schistosoma species.
c
Percent of indeterminate test results among positive test results for all schistosomiasis cases/S. mansoni/S. haematobium.
d
Data are percentages (95% CI). NA, not applicable (test interpretation schedule provided by the manufacturer does not include indeterminate results).