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. 1999 Aug 17;96(17):9449–9451. doi: 10.1073/pnas.96.17.9449

Figure 1.

Figure 1

Effect of IL-1 on excitotoxic damage. (A) Coinfusion of recombinant IL-1β (10 ng) with the excitotoxin S-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (S-AMPA) markedly exacerbates brain damage (adapted from ref. 30) determined histologically 48 h later. (B) In contrast, in primary cultures of cortical rat neurones cell death (assessed by lactic dehydrogenase release) induced by S-AMPA is significantly inhibited by IL-1β (500 ng/ml) (adapted from ref. 29). ∗∗, P < 0.01 vs. respective S-AMPA group.