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. 2004 Jan 20;101(5):1374–1379. doi: 10.1073/pnas.0307014101

Fig. 4.

Fig. 4.

Identification of a core progenitor cell expression program expressed in diverse regions of the CNS. (A–D) Hierarchical cluster analysis of gene expression in progenitor (4N) cells from three regions of the developing CNS, compared to adult brain: retina, cerebral cortex, and cerebellum. The complete cluster analysis is shown in A. Examples are shown of genes enriched in retinal progenitor cells (B), genes commonly enriched in progenitor cells from all three regions (C), and enriched in brain (D). (E–H) In situ hybridization studies of the developmental expression within the forebrain of a subset of the core set of retinal progenitor cell-enriched transcripts also found enriched in cortical and cerebellar progenitor cells. All images are of coronal sections the E14.5 mouse forebrain. Genes are as marked on each panel. Note the high level of expression of each gene within the ventricular zone (VZ) of the developing cortex (arrowheads) and the sharply localized expression of SFRP2 at the junction between the cortical and subcortical VZs. MARCKS is expressed within postmitotic neurons in the cortical plate, in addition to its expression within cortical VZ progenitor cells.