Fig 3.

Expressing EHEC NleH effectors alters Citrobacter virulence. (A) C3H/HeJ survival. The survival (percentage of initial population) of C3H/HeJ mice is plotted as a function of time after oral gavage with indicated C. rodentium strains (n = 7 or 8/group). Asterisks indicate significantly different survival rates compared with wild-type infection. (B) Citrobacter colonization. Colonization (CFU/g mouse colon) of indicated C. rodentium strains (7 days postgavage) in C57BL/6J mice (n = 8/group). The asterisk indicates significantly different colonization magnitudes. (C) TNF expression. Relative TNF mRNA expression levels from colons obtained from C57BL/6J mice (7 days postgavage) infected with the indicated C. rodentium strains. Asterisks indicate significantly different TNF expressions compared with wild-type infection.