Table 2. Percentage of HUVECs positive for specified adhesion molecule expression under control conditions and after exposure to an inflammatory stimulus in the presence and absence of BAY 41-2272 (1 μM).
Adhesion molecule expressed | Control | + IL-1β (200 ng/ml) | + IL-1β (200 ng/ml) + BAY 41-2272 (1 μM) | + Histamine (100 μM) | + Histamine (100 μM) + BAY 41-2272 (1 μM) |
---|---|---|---|---|---|
P-selectin | 0.39 ± 0.15 | 3.90 ± 0.93* | 1.77 ± 0.17** | 12.28 ± 1.63* | 4.34 ± 0.95** |
E-selectin | 5.89 ± 0.13 | 7.11 ± 0.32* | 6.69 ± 0.41 | ||
ICAM-1 | 0.19 ± 0.17 | 90.09 ± 0.47* | 89.78 ± 1.92 |
, P < 0.05, significantly greater than control; **, P < 0.05, significantly lower than inflammatory stimulus alone; n > 5.