Figure 5.
Resveratrol improves PA atrogin-1 mRNA expression in MCT-induced pulmonary hypertension. PAs were collected for real time PCR analysis after acquisition of hemodynamic indices (figure 1) from Sal or MCT injected rats treated with resveratrol (R, 3 mg/kg/day) or sildenafil (S, 175 μg/kg/day) from 28–42d. Effects of resveratrol on relative mRNA expression for atrogin-1 (A), MuRF-1 (B), eNOS (C) and Kv1.5 (D). Data are expressed as mean target mRNA expression ± SEM is expressed relative to β-actin mRNA expression (ΔΔCt). *P < 0.05 versus Sal; #P < 0.05 versus MCT.