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. Author manuscript; available in PMC: 2012 Jun 8.
Published in final edited form as: Cold Spring Harb Symp Quant Biol. 2011 Apr 5;75:453–460. doi: 10.1101/sqb.2010.75.050

Figure 3. Three generations of engineered chromosome regions.

Figure 3

(A–B) Gene amplication produces both condensed (A) and extended (B) amplified chromosome regions. (C) Multi-copy plasmid insertions form condensed, hetereochromatic masses. (D) Multi-copy insertion of BACs containing active gene loci form extended large-scale chromatin conformations typical of surrounding, endogenous chromatin. DAPI (red), GFP-lac repressor (green). Scale bar = 2 μm.