Table 1.
The role and therapeutic potential of prohibitin in disease.
| PHB1 function |
Cell type | Subcellular localization |
Disease | Potential therapeutic strategy |
Reference |
|---|---|---|---|---|---|
|
Combat oxidative stress |
Pancreatic β- cells |
Mitochondria/ nucleus |
Type 2 diabetes |
Increase PHB1 levels |
[88] |
| Intestinal epithelial cells |
Mitochondria | IBD | Increase PHB1 levels |
[13, 19] | |
| Cardiomyocytes | Mitochondria | Myocardium injury |
Increase PHB1 levels |
[16] | |
| Hepatocytes | Mitochondria | Hepatitis C Virus |
Restore PHB1 function |
[17] | |
|
Activate p53 and modulate Rb tumor suppressors |
Cancer cell lines (T47D, MCF7, SW13, C33A, Ramos) |
Nucleus | Cancer | Increase nuclear PHB1 levels |
[54–56] |
|
c-Raf activation by Ras oncogene |
HeLa | Plasma membrane |
Cancer | Decrease cell surface PHB1 |
[61] |
|
Vascular Receptor |
Adipose vasculature |
Plasma membrane |
Obesity | Target PHB1 | [92, 93] |