Table 1.
Scheme of experiment 1 for evaluation of completely novel oral regimens
| Regimen type and group | Drug combinationa | No. of mice sacrificed/group atb: |
|||||
|---|---|---|---|---|---|---|---|
| D−13 | D0 | M1 | M2 (+3) | M3 (+3) | M4 (+3) | ||
| Control regimens | |||||||
| Untreated | 6 | 6 | |||||
| A | RIF + PZA + INHc | 5 | 4 | (15) | (15) | ||
| Test regimens | |||||||
| B | TMC + PNU + CFZ + PA-824 | 5 | 4 (15) | (15) | (15) | ||
| C | TMC + PNU + CFZ | 5 | 4 (15) | (15) | (15) | ||
| D | TMC + PNU + PA-824 | 5 | 4 (15) | (15) | (15) | ||
| E | TMC + CFZ + PA-824 | 5 | 4 (15) | (15) | (15) | ||
| F | PNU + CFZ + PA-824 | 5 | 4 (15) | (15) | (15) | ||
| Total (n = 321) | 6 | 6 | 30 | 24 (75) | (90) | (90) | |
a
Drug doses (in mg/kg) were as follows: RIF (10), PZA (150), INH (10), TMC (25), PNU (50), CFZ (20), PA-824 (50).
b
Time points are shown in days (e.g., D−13, day −13; D0, day 0) or months (e.g., M2, 2 months) of treatment. The notation “(+3)” indicates that the mice were held for 3 months after the completion of treatment at the indicated time point. When values are reported only in parentheses, this indicates that all mice in the group were sacrificed after the additional holding period posttreatment.
c
For the RIF + PZA + INH regimen, PZA was given for the first 2 months only.