Table 2.
Scheme for experiment 2 to determine whether RPT, CFZ, or PNU increases the sterilizing activity of TMC plus PZA
| Drug regimena | No. of mice sacrificed/group at time pointb: |
|||||
|---|---|---|---|---|---|---|
| D−16 | D0 | W4 (+12) | W6 (+12) | W8 (+12) | W10 (+12) | |
| Control regimens | ||||||
| Untreated | 4 | 4 | ||||
| RPT + PZA + MXF | (15) | (15) | ||||
| TMC + PZA | (15) | (15) | (15) | |||
| Test regimens | ||||||
| TMC + PZA + RPT | (15) | (15) | ||||
| TMC + PZA + CFZ | (15) | (15) | ||||
| TMC + PZA + PNU | (15) | (15) | ||||
| TMC + PZA + RPT + CFZ | (15) | (15) | ||||
| Total (n = 203) | 4 | 4 | (15) | (75) | (75) | (30) |
a
Drug doses (in mg/kg) were as follows: RPT (10), PZA (150), MXF (100), TMC (25), CFZ (20), PNU (50).
b
Time points are shown in days (D−16, day −16; D0, day 0) or weeks (e.g., W4, 4 weeks) of treatment. The notation “(+12)” indicates that the mice were held for 12 weeks after the completion of treatment at the indicated time point. When values are reported only in parentheses, this indicates that all mice in the group were sacrificed after the additional holding period posttreatment.