Table 4.

Distribution of mutations in katG gene and the inhA promoter region of 113 INH^r and 45 INH^s M. tuberculosis isolates from Nepal

Locus	Amino acid change(s)	Nucleotide change(s)	No. (%) of isolates
			INHr (n = 113)	INHs (n = 45)
katG 315	Ser→Thr	AGC→ACC	86 (76.1)	0 (0.0)
	Ser→Thr	AGC→ACT	1 (0.9)	0 (0.0)
	Ser→Asn	AGC→AAC	1 (0.9)	0 (0.0)
katG 299	Gly→Ser	GGC→AGC	1 (0.9)	0 (0.0)
katG 329	Asp→Ala	GAC→GCC	1 (0.9)	0 (0.0)
katG 341	Trp→Gly	TGG→GGG	1 (0.9)	0 (0.0)
katG 275 and katG 315	Thr→Ala and Ser→Thr	ACC→GCC and AGC→ACC	1 (0.9)	0 (0.0)
inhA −15	NAb	C→T	6 (5.3)	0 (0.0)
inhA −8	NA	T→C	1 (0.9)	0 (0.0)
katG 285 and inhA −15	Gly→Asp and NA	GGC→GAC and C→T	1 (0.9)	0 (0.0)
katG 289 and inhA −15	Glu→Ala and NA	GAG→GCG and C→T	1 (0.9)	0 (0.0)
katG 289, katG 296, and inhA −15	Glu→Ala, Met→Val, and NA	GAG→GCG, ATG→GTG, and C→T	1 (0.9)	0 (0.0)
katG 315 and inhA −12	Ser→Thr and NA	AGC→ACC and T→A	1 (0.9)	0 (0.0)
katG 315 and inhA −15	Ser→Thr and NA	AGC→ACC and C→T	3 (2.7)	0 (0.0)
Wild typea	None	None	7 (6.2)	45 (100)

^aThat is, there were no mutations in sequenced regions of katG and inhA promoter.

^bNA, not applicable.