Table 1.
Pharmacokinetic/pharmacodynamic values for moxifloxacin and rifampin alone and in combination
| Treatment | MIC (mg/liter) | Fraction unbound | AUC0–24 (mg · h/liter) | SE (AUC) | fAUC/MIC (h) |
|---|---|---|---|---|---|
| Moxifloxacin alone (400 mg/kg) | 0.5 | 0.5 | 56 | 10.0 | 56 |
| Moxifloxacin alone (400 mg/kg) after 18 doses | 0.5 | 0.5 | 50 | 3.3 | 50 |
| Moxifloxacin (400 mg/kg) plus rifampin (10 mg/kg) after 18 doses | 0.5 | 0.5 | 59 | 5.4 | 59 |
| Rifampin alone (10 mg/kg) after 1 dose | 0.10 | 0.15 | 110.0 | 16.0 | 165 |
| Rifampin alone (10 mg/kg) after 18 dosesa | 0.10 | 0.15 | 31.6 | 5.6 | 47 |
| Rifampin (10 mg/kg) plus moxifloxacin (400 mg/kg) after 18 dosesb | 0.10 | 0.15 | 19.5 | 3.2 | 29 |
a
The rifampin AUC after multiple doses was 3- to 4-fold lower than that seen after a single dose (P < 0.01; Dunnett's multiple-comparison test).
b
The rifampin AUC after multiple doses was reduced further in the presence of moxifloxacin (P < 0.01; Dunnett's multiple-comparison test).