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Structure of 6-NDA and its in vitro antifungal activity compared to amphotericin B. (A) Structure of 6-NDA; (B) dose response curve for 6-NDA; (C) dose response curve for amphotericin B. In panels A and B, broth microdilution assays were performed against the fungal pathogens C. albicans, A. fumigatus, and T. mentagrophytes according to CLSI guidelines (9). The “% Growth” values were calculated from the means from two replicate experiments.
