Table 2.
Functional distribution of 6-NDA-responding genes in C. albicans
| GO terma | 6-NDA data set frequency (%) | Genome frequency (%) | P value | Genes annotated to the GO termb |
|---|---|---|---|---|
| Upregulated genes | ||||
| Response to stress | 10.48 | 8.59 | 4.57E−02 | CAT1, CDR1, DDR48, GAL10, HAC1, NCE103, RPN4, RTA3, SOD2, SOD4, SNQ2, SVF1, orf19.2175, orf19.2458, orf19.251 |
| Carbohydrate metabolism | 8.87 | 4.58 | 1.57E−02 | ADH2, AMS1, CWH8, GAL10, GCA1, INO1, MNN1, PCK1, UTR2, orf19.3994, orf19.753 |
| Lipid metabolism | 6.45 | 4.21 | 2.11E−02 | AUR1, CWH8, GIT1, INO1, LAG1, MIT1, PLB1, SEC14, orf19.6007, orf19.7441 |
| Downregulated genes | ||||
| Amino acid metabolism | 22.44 | 3.77 | 1.19E−27 | AAT1, ARG4, ARG8, ARO1, ARO3, ARO4, ARO8, ASN1, GCV2, GCV3, HIS1, HIS4, HIS5, HIS7, HOM2, HOM3, HOM6, ILV1, ILV2, ILV3, ILV6, LEU4, LEU42, LYS1, LYS2, LYS4, MET13, MET2, MET6, MIS11, PRO1, PRO2, SAM4, SER1, SER33, STR2, THR1, TRP2, TRP3, TRP4, TRP5, URA2, VAS1 |
| Translation | 20.08 | 6.71 | 1.43E−12 | RPL10A, RPL11, RPL13, RPL14, RPL15A, RPL16A, RPL18, RPL19A, RPL2, RPL20B, RPL21A, RPL24A, RPL25, RPL27A, RPL28, RPL3, RPL32, RPL37B, RPL43A, RPL4B, RPL5, RPL9B, RPP1A, RPP2A, RPP2B, RPS13, RPS14B, RPS15, RPS17B, RPS19A, RPS21, RPS22A, RPS23A, RPS24, RPS27, RPS28B, RPS3, RPS7A |
| Chromosome organization | 6.69 | 4.93 | 4.65E−02 | HHF1, HHF22, HHO1, HHT2, HHT21, HTA1, HTA2, HTB1, NAT4, orf19.1052 |
| Lipid metabolism | 4.72 | 4.21 | 4.71E−02 | ACS1, ATF1, ERG1, ERG3, ERG5, ERG6, ERG9, ERG11, ERG13, ERG251, FET3, HMO1, YMC1, orf19.85, orf19.4581 |
a
Data (139 upregulated genes and 271 downregulated genes) were organized into GO-based biological process categories using the GO Term Mapper tool (http://go.princeton.edu/cgi-bin/GOTermMapper). Significantly overrepresented categories (P ≤ 0.05) with a 6-NDA data set frequency of ≥4.5% are listed.
b
Within each GO category, a subset of genes are shown that are relevant to the overall biological response to 6-NDA.