Table 2.
In vitro efficacy of antimalarial drug combinations against P. falciparum clones 3D7, W2mef, and Dd2 assessed by isobolographic analysisa
| Drug combination | 3D7 |
W2mef/Dd2 |
||||
|---|---|---|---|---|---|---|
| I (95% CI) | ΣFIC (95% CI) | Interpretation | I (95% CI) | ΣFIC (95% CI) | Interpretation | |
| Fenofibric acid-chloroquine | 0.23 (−0.06 to 0.51) | 0.99 (0.95 to 1.02) | Indifferent | −1.07 (−2.08 to −0.07) | 1.19 (1.02 to 1.36) | Antagonistic |
| Fenofibric acid-dihydroartemisinin | −0.26 (−1.02 to 0.50) | 1.11 (0.99 to 1.21) | Indifferent | −0.48 (−1.31 to 0.36) | 1.11 (1.02 to 1.21) | Indifferent |
| Fenofibric acid-atorvastatin | −0.33 (−1.92 to 1.26) | 1.19 (1.02 to 1.35) | Indifferent | −0.81 (−1.52 to −0.09) | 1.08 (0.96 to 1.19) | Indifferent |
| Fenofibrate-chloroquine | −0.67 (−1.40 to 0.05) | 1.08 (0.98 to 1.12) | Indifferent | −0.41 (−1.01 to 0.19) | 1.01 (0.93 to 1.10) | Indifferent |
| Fenofibrate-dihydroartemisinin | 0.36 (−0.83 to 1.55) | 1.16 (1.03 to 1.30) | Indifferent | ND | ND | ND |
| Gemfibrozil-chloroquine | −1.53 (−2.44 to −0.62) | 1.12 (1.01 to 1.23) | Antagonistic | −0.55 (−1.80 to 0.73) | 1.19 (0.99 to 1.40) | Indifferent |
| Gemfibrozil-dihydroartemisinin | −1.34 (−3.34 to 0.66) | 1.20 (0.95 to 1.45) | Indifferent | −0.25 (−2.10 to 1.61) | 1.15 (0.95 to 1.40) | Indifferent |
a
Data are the interaction factor (I) and the summed fractional inhibitory concentration (ΣFIC) with 95% confidence intervals (CIs). The assessment of interaction is based on both I and ΣFIC data (see the text). Data for CQ-resistant strains are presented together. ND, not determined.