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Effects of various antimalarial drugs on INa ion current. Values represent mean ± SEM of five preparations. Five or six concentrations of drugs were used, and the concentrations ranged from 0.003/0.1 to 3/10 μM for PQP without or with 2.4 or 7.2 μM DHA, from 1 to 100 μM for DHA, from 0.1 to 10 μM for chloroquine, from 0.3 to 30 μM for lumefantrine (LUM; with 0.18 μM artemether [ART]), and from 0.1 to 10 nM for dofetilide.
