Skip to main content
. 2012 Jun;56(6):3423–3427. doi: 10.1128/AAC.06191-11

Table 3.

Results on conjugative transfer experiments and QRDR statusd

Strain PMQR determinant(s) Specimen MIC (μg/ml)a
 MDR phenotypeb QRDRc mutation(s) in:
NAL OLA CIP NOR OFX LVX gyrA parC
U027 aac(6′)-Ib-cr Human urine 512 8 0.25 1 0.5 0.25 AMP, TET, SXT, CHL, GEN, CEF, AMK S83L WT
T-U027 aac(6′)-Ib-cr 4 8 0.016 0.06 0.03 0.03 AMP, TET, SXT, CHL, GEN
U054 aac(6′)-Ib-cr Human urine >1024 4 64 256 32 16 AMP, TET, SXT, CHL, GEN, CEF, CAZ, ATM S83L, D87N S80I
T-U054 aac(6′)-Ib-cr 4 8 0.016 0.06 0.03 0.03 AMP
U072 aac(6′)-Ib-cr Human urine >1024 4 1 8 2 0.5 AMP, TET, SXT, GEN, STR, CEF S83L S80I
T-U072 aac(6′)-Ib-cr 8 4 0.016 0.06 0.03 0.03 AMP, TET, SXT, STR, CEF
U175 aac(6′)-Ib-cr Human urine >1024 16 128 256 32 32 AMP, TET, SXT, CHL, STR, CEF, CAZ, ATM, AMK S83L, D87N S80I
T-U175 aac(6′)-Ib-cr 4 4 0.008 0.06 0.03 0.03 AMP, TET, SXT, CHL, STR, CEF
U220 aac(6′)-Ib-cr Human urine >1024 8 256 256 32 16 AMP, TET, SXT, GEN, STR, CEF, CAZ S83L, D87N S80I
T-U220 aac(6′)-Ib-cr 4 8 0.016 0.06 0.03 0.03 AMP, TET, SXT, STR, CEF
U242 aac(6′)-Ib-cr Human urine >1024 16 128 256 32 16 AMP, TET, CEF S83L, D87N S80I
T-U242 aac(6′)-Ib-cr 4 8 0.016 0.06 0.06 0.03 AMP, TET
U015 qepA Human urine >1024 16 128 >256 32 16 AMP, TET, SXT, GEN, STR, CEF, CAZ, CTX, ATM, AMK S83L, D87N S80I
T-U015 qepA 4 8 0.03 0.25 0.03 0.016 AMP, TET, SXT, GEN, CEF, CTX, ATM, AMK
U155 qepA Human urine >1024 4 128 256 16 16 AMP, TET, SXT, CHL, GEN, STR, CEF, CAZ, CTX, ATM S83L, D87N S80I
T-U155 qepA 4 8 0.06 0.25 0.06 0.03 AMP, GEN, CEF, CAZ, CTX, ATM
U222 qepA Human urine >1024 8 >256 >256 64 32 AMP, TET, SXT, CHL, GEN, STR, PIP, CEF, CTX, AMK S80L, D87N S80I
T-U222 qepA 4 8 0.016 0.125 0.03 0.016 AMP, SXT, CHL, GEN, PIP, CEF, AMK
C023 qnrA1, oqxAB, aac(6′)-Ib-cr Pig feces >1024 128 8 32 16 8 AMP, TET, SXT, GEN, STR S83L S80I
T-C023 qnrA1, aac(6′)-Ib-cr 16 8 0.25 1 0.5 0.25 AMP, GEN
C040 qnrA3, aac(6′)-Ib-cr Pig feces 32 2 ≤0.125 0.5 0.25 0.25 AMP, TET, SXT, GEN, STR WT WT
T-C040 qnrA3, aac(6′)-Ib-cr 16 4 0.125 0.5 0.25 0.125 AMP, TET, SXT
C041 qnrA3, aac(6′)-Ib-cr Pig feces 16 2 ≤0.125 0.5 0.25 0.25 AMP, TET, SXT, GEN, STR WT WT
T-C041 qnrA3, aac(6′)-Ib-cr 16 4 0.25 0.5 0.25 0.125 AMP, TET, SXT
C042 qnrA3, aac(6′)-Ib-cr Pig feces 16 2 ≤0.125 0.5 0.5 0.25 AMP, TET, SXT, GEN, STR WT WT
T-C042 qnrA3, aac(6′)-Ib-cr 16 4 0.125 0.5 0.25 0.125 AMP, TET, SXT
C053 qnrS1 Pig feces 8 8 ≤0.125 0.25 0.5 0.25 AMP, CHL WT WT
T-C053 qnrS1 32 4 0.25 0.5 1 0.5 AMP, CHL
C058 qnrS1 Pig feces 16 32 ≤0.125 0.25 0.5 0.25 AMP, TET, SXT WT WT
T-C058 qnrS1 32 4 0.25 0.5 1 0.5 AMP
C111 qnrS1 Pig feces 256 8 0.5 1 4 2 AMP, TET, SXT, CHL, STR, PIP S83L WT
T-C111 qnrS1 32 4 0.25 0.5 1 0.5 AMP, TET, SXT, CHL, PIP
C112 qnrS1 Pig feces 256 8 0.5 1 8 2 AMP, TET, SXT, CHL, STR, PIP S83L WT
T-C112 qnrS1 32 4 0.25 0.5 1 0.5 AMP, TET, SXT, CHL, PIP
C113 qnrS1 Pig feces 256 16 0.5 1 4 4 AMP, TET, SXT, CHL, STR, PIP S83L WT
T-C113 qnrS1 32 4 0.25 0.5 1 0.5 AMP, TET, SXT, CHL, PIP
C194 qnrS1 Pig feces 16 32 ≤0.125 0.25 0.5 0.25 AMP, TET, GEN, STR, FOF WT A56T
T-C194 qnrS1 32 4 0.125 0.5 1 0.5 AMP
C261 qnrS1 Human feces 32 4 ≤0.125 0.25 0.5 0.25 AMP, TET, SXT WT WT
T-C261 qnrS1 32 4 0.25 0.5 1 0.5 TET, SXT
C263 qnrS1 Dog feces 16 8 ≤0.125 0.5 0.5 0.5 AMP, TET, SXT, GEN, STR, PIP WT WT
T-C263 qnrS1 16 4 0.125 0.5 1 0.5 AMP
C389 qnrS1 Chicken feces 32 8 ≤0.125 0.25 0.5 0.5 AMP, TET, SXT, FOF WT WT
T-C389 qnrS1 32 4 0.25 0.5 1 0.5 TET, SXT
U033 qnrS1 Human urine >1024 4 16 128 64 32 AMP, TET, GEN, PIP S83L, D87N S80I
T-U033 qnrS1 16 8 0.5 1 1 0.5 AMP, TET, GEN, PIP
U116 qnrS1 Human urine >1024 16 32 128 64 64 AMP, TET, GEN, PIP S83L, D87N S80I
T-U116 qnrS1 32 8 0.25 0.5 1 0.5 AMP, TET, GEN, PIP
U145 qnrS1 Human urine >1024 32 64 256 128 64 AMP, TET, GEN, CEF S83L, D87N S80I
T-U145 qnrS1 32 4 0.25 0.5 1 0.5 AMP, TET
C193 qnrS1, oqxAB Pig feces 64 64 0.25 0.5 2 1 AMP, TET, SXT, GEN, STR, FOF WT A56T
T-C193 qnrS1 32 4 0.25 0.5 1 0.5 AMP, TET, SXT
C544 qnrS1, oqxAB Chicken feces 64 128 0.25 1 2 0.5 AMP, TET, SXT, CHL, GEN, STR, PIP, CEF, CTX, AMK, FOF WT WT
T-C544 qnrS1 32 4 0.125 0.5 1 0.5 AMP, TET, SXT, CHL, STR
C052 qnrS1, oqxAB Pig feces 32 128 0.25 0.5 1 0.5 AMP, TET, SXT, CHL, GEN, STR, PIP WT WT
T-C052 qnrS1 32 4 0.125 0.5 1 0.5 AMP, CHL
C054 qnrS1, oqxAB Pig feces 32 64 0.25 0.5 1 0.5 AMP, TET, SXT, CHL, GEN, STR WT WT
T-C054 qnrS1 32 8 0.125 0.5 1 0.5 AMP, CHL
C055 qnrS1, oqxAB Pig feces 32 64 ≤0.125 0.5 1 0.5 AMP, TET, SXT, CHL, GEN, STR WT WT
T-C055 qnrS1 16 4 0.125 0.5 1 0.5 AMP, CHL
C594 qnrS1, oqxAB Dust 32 128 ≤0.125 0.5 1 0.5 TET, SXT, CHL WT WT
T-C594 qnrS1, oqxAB 64 32 0.25 1 1 0.5 TET, SXT, CHL
C709 qnrS1, oqxAB Dust 32 128 0.25 0.5 1 0.5 AMP, TET, AMK, SXT, CHL WT WT
T-C709 qnrS1, oqxAB 64 32 0.25 1 2 0.5 TET, SXT, CHL
C056 qnrS1, oqxAB, aac(6′)-Ib-cr Pig feces 128 128 1 2 2 0.5 AMP, TET, SXT, CHL, GEN, STR, FOF WT WT
T-C056 oqxAB, aac(6′)-Ib-cr 32 256 0.03 0.125 0.06 0.03 AMP, TET, SXT, CHL, GEN
C578 qnrS1, aac(6′)-Ib-cr Duck feces 32 32 0.5 1 1 0.5 AMP, TET, SXT WT WT
T-C578 qnrS1, aac(6′)-Ib-cr 32 8 0.5 1 1 0.5 AMP, TET, SXT
C197 qnrS2, aac(6′)-Ib-cr Pig feces 32 4 0.25 1 0.5 0.25 AMP, TET, SXT, STR WT WT
T-C197 qnrS2, aac(6′)-Ib-cr 32 4 0.5 1 1 0.5 AMP, TET, SXT
C265 oqxAB, aac(6′)-Ib-cr Chicken liver >1024 128 8 32 8 4 AMP, TET, SXT, CHL, GEN, CEF S83L, D87N S80R
T-C265 oqxAB, aac(6′)-Ib-cr 32 64 0.03 0.125 0.06 0.03 AMP, TET, SXT, CHL
C324 oqxAB, aac(6′)-Ib-cr Chicken liver >1024 256 32 64 16 8 AMP, TET, SXT, CHL, GEN, CEF, CAZ S83L, D87N S80I
T-C324 oqxAB, aac(6′)-Ib-cr 16 128 0.016 0.125 0.06 0.03 AMP, TET, SXT, CHL
C327 oqxAB, aac(6′)-Ib-cr Chicken liver >1024 512 64 128 32 16 AMP, TET, SXT, CHL, GEN, CEF, ATM, AMK, FOF, NIT S83L, D87G S80I
T-C327 oqxAB, aac(6′)-Ib-cr 16 128 0.016 0.125 0.06 0.03 AMP, TET, SXT, CHL
C034 oqxAB Pig feces >1024 128 8 32 16 8 AMP, TET, SXT, PIP, GEN, STR S83L, D87Y S80I
T-C034 oqxAB 32 64 0.016 0.125 0.06 0.03 TET, GEN
C671 oqxAB Chicken feces >1024 128 16 32 16 8 AMP, TET, SXT, CHL, STR, CEF S83L, D87N S80I
T-C671 oqxAB 32 64 0.03 0.125 0.06 0.03 AMP, TET, SXT, PIP, CEF
U080 oqxAB Human urine >1024 256 64 128 32 16 AMP, TET, SXT, CHL, STR S83L, D87N S80I
T-U080 oqxAB 32 64 0.03 0.125 0.06 0.03 AMP, TET, SXT, CHL
J53 Azr 4 8 0.008 0.016 0.03 0.016
a

CIP, ciprofloxacin; LVX, levofloxacin; NAL, nalidixic acid; NOR, norfloxacin; OFX, ofloxacin; OLA, olaquindox.

b

Multidrug resistance (MDR) phenotype abbreviations are as follows: AMK, amikacin; AMP, ampicillin; ATM, aztreonam; CAZ, ceftazidime; CEF, cephalothin; CHL, chloramphenicol; CTX, cefotaxime; FOF, fosfomycin; GEN, gentamicin; NIT, nitrofurantoin; PIP, piperacillin; STR, streptomycin; SXT, trimethoprim-sulfamethoxazole; TET, tetracycline.

c

QRDR, quinolone resistance-determining region; S83L, mutation of the amino acid at codon 83 from S to L (etc.); WT, wild type (i.e., no mutation).

d

The “T-” prefix indicates a transconjugant.