Table 4.
Pharmacokinetic characteristics of ferroquine under fasted and fed conditions after a single dose of 100 mg
| PK parameter | Value for the parameter under the indicated condition (mean ± SD [CV])a |
|
|---|---|---|
| Fasted | Fed | |
| tlag (h)b | 0.00 (0.00–0.50) | 0.78 (0.00–3.02) |
| tmax (h)b | 2.00 (1.03–8.00) | 5.05 (5.00–10.00) |
| Cmax (ng/ml) | 33.8 ± 12.0 (36) | 29.7 ± 10.1 (34) |
| AUCO–24 (ng · h/ml) | 469 ± 119 (25) | 407 ± 170 (42) |
| AUC (ng · h/ml) | 4,420 ± 1,340 (30) | 4,860 ± 2,530 (52) |
| t1/2z (days) | 12.9 ± 3.60 (28) | 14.6 ± 6.56 (45) |
a
CV, coefficient of variation expressed as a percentage.
b
Values are median (range).