. 2012 Jun;56(6):2868–2872. doi: 10.1128/AAC.06062-11

Table 1.

Correlation between OPN promoter activity and OPN secretion and maximal serum concentrations of studied quinolones

Drug	Correlation between OPN promoter activity and OPN secretion^a		Dose (mg)	C_max^b (μg/ml)
Drug	R² value	P value	Dose (mg)	C_max^b (μg/ml)
CIP	0.881	0.061	750 (×2)^c	3.5
GRN	0.988	0.006^**	400 (×1)	5.8
MFX	0.929	0.036^*	400 (×1)	3.1
GAT	0.993	0.003^**	400 (×1)	4.0
SPX	0.756	0.131	400 (×1)	1.0
STF	0.913	0.045^*	200 (×1)	1.9

Luciferase assay and ELISA data from a 48-h quinolone treatment of A549 cells expressing percent increase above the value for the control were assessed by simple regression analysis. **, P < 0.01; *, P < 0.05.

C_maxs from previous studies (1, 22).

Data in parentheses represent frequency per day.