Table 1.
Demographic, anthropometric, and diagnostic features of participants
| Parametera | Value |
||||
|---|---|---|---|---|---|
| PA-824 |
HRZE | ||||
| 50 mg | 100 mg | 150 mg | 200 mg | ||
| No. of participants | 15 | 15 | 15 | 16 | 8 |
| Age, mean (yr ± SD) | 30.5 ± 9.7 | 29.6 ± 9.3 | 26.9 ± 8.9 | 25.3 ± 6.2 | 33.3 ± 14.1 |
| BMI, mean (kg/m2 ± SD) | 19.23 ± 2.804 | 19.32 ± 3.604 | 19.00 ± 2.048 | 19.57 ± 2.221 | 20.35 ± 2.170 |
| Wt, mean (kg ± SD) | 53.53 ± 7.359 | 55.82 ± 9.899 | 51.58 ± 6.812 | 52.17 ± 7.968 | 58.17 ± 6.724 |
| Male [n (%)] | 7 (46.7) | 8 (53.3) | 7 (46.7) | 7 (43.8) | 6 (75.0) |
| HIV positive [n (%)] | 0 | 2 (13.3) | 1 (6.7) | 2 (13.3) | 1 (12.5) |
| CD4 (mean no./cmm ± SD) | 753 ± 305 | 589 ± 235 | 691 ± 225 | 605 ± 233 | 563 ± 136 |
| Baseline sputum CFU (log CFU/ml sputum ± SD) | 6.1 ± 0.6 | 5.8 ± 0.9 | 6.0 ± 0.7 | 6.1 ± 1.2 | 6.1 ± 1.0 |
| Baseline TTP (h ± SD) | 100 ± 11 | 115 ± 32 | 103 ± 20 | 104 ± 36 | 108 ± 26 |
a
BMI, body mass index.