Table 1.
Summary of the in vitro activity of telavancin combined with colistin versus bacterial type strains
| Organism | Strain | MIC, in μg/ml (method) |
Synergy testing results |
||||||
|---|---|---|---|---|---|---|---|---|---|
| TLV (Etest) | COL (Etest) | COL (microtiter dilution) | COL (shaken in broth)a | Lowest FICI | SBPI | TLV MIC by Etest (concn of COL in agar)b | Synergy by time-kill? | ||
| A. baumannii | ATCC 19606 | >32 | 0.125 | 1 | 2 | 0.252 | 8 | 0.25 (0.125) | Yes |
| E. coli | NCTC 12241 | >32 | 0.125 | 2 | 16 | 0.141 | 8.5 | 0.25 (0.125) | No |
| E. coli | NCTC 11954 | >32 | 0.5 | 1 | 8 | 0.252 | 8 | 1 (0.125) | Yes |
| E. aerogenes | NCTC 9735 | >32 | 0.25 | 1 | 32 | 0.5 | 6 | 0.125 (0.25) | Yes |
| E. cloacae | NCTC 10005 | >32 | >256c | >8 | >256 | 2 | < 0.13 | >32 (0.75) | No |
| E. cloacae | NCTC 13380 | >32 | 0.125 | 0.25 | 0.5 | 2 | 8 | 1 (0.125) | No |
| K. pneumoniae | NCTC 13368 | >32 | 0.5 | 1 | 8 | 0.258 | 3 | 1 (0.25) | Yes |
| P. mirabilis | NCTC 13376 | >32 | >256c | >8 | >256 | 2 | < 0.13 | >32 (0.75) | No |
| P. aeruginosa | NCTC 27853 | >32 | 0.5 | 1 | 2 | 2 | 2 | >32 (0.125) | Yes |
| S. marcescens | NCTC 13382 | >32 | >256c | >8 | >256 | 2 | < 0.13 | >32 (0.75) | No |
| S. maltophilia | NCTC 10258 | >32 | 0.125 | 8 | 32 | 0.033 | 10 | 1 (0.25) | No |
a
Concentration of COL required to prevent visible growth in 10 ml of Iso-Sensitest broth with vigorous shaking at 37°C for 24 h.
b
Highest concentration (in μg/ml) supporting semiconfluent growth on Iso-Sensitest agar.
c
COL-resistant isolate.