Table 2.
Activity of TLV in combination with COL against clinical isolates
| Species (no. of isolates) | TLV MIC (μg/ml) results on Iso-Sensitest + COLa |
% susceptibleb | ||
|---|---|---|---|---|
| MIC50 | MIC90 | Mean fold reduction | ||
| A. baumannii (35) | 2 | 16 | >4.5 | 20 |
| S. maltophilia (8) | 2 | 2 | >5 | 12.5 |
| Enterobacteriacae (23) | 0.5 | 4 | >6 | 65 |
| All isolates (66) | 2 | 12 | >5 | 35 |
a
Data were obtained using the highest concentration of COL (0.25 to 0.75 μg/ml) able to support semiconfluent growth on Iso-Sensitest agar for each isolate.
b
Based on the FDA/EUCAST breakpoint for staphylococci of ≤1 μg/ml.