Table 1.
In vitro IC50s of selected arylmethanols for NTS and adult S. mansoni 72 h posttreatmenta
| Methanol group | Compound | IC50 (SD) [μM] |
|
|---|---|---|---|
| NTS | Adult worms | ||
| 4-Quinoline | Mefloquine | 6.1 (1.3) | 11.4 (6.4) |
| 9-Phenanthrene | 1 (WR171669) | 1.9 (0.4) | 7.2 (1.6) |
| 2 (WR178460) | 0.2 (0.2) | 7.1 (6.4) | |
| 3 (WR190420) | 3.0 (2.6) | 5.4 (1.7) | |
| 4-Pyridine | 4 (WR148946) | 12.1 (8.2) | >52.2 |
| 5 (WR151312) | 2.7 (3.1) | 4.0 (3.4) | |
| 6 (WR154904) | 0.2 (0) | 5.3 (6.2) | |
| 7 (WR180409) | 0.9 (0.2) | 6.1 (4.7) | |
| 4-Quinoline | 8 (WR7573) | 1.4 (1.3) | 2.7 (0.2) |
| 9 (WR7930) | 0.2 (0.3) | 3.5 (1.6) | |
a
Experiments were carried out 3 times in duplicate for NTS (n = 6) and 3 times for adult schistosomes (n = 3) for each tested drug. SD, standard deviation.