Table 2.
Effect of selected arylmethanols on worm burden in mice harboring adult S. mansoni (patent infection, 49 days), stratified by sex and worm distributiona
| Compound (100 mg/kg) | No. of mice investigated | No. of mice that died | No. of mice cured | Mean no. of worms (SD) |
TWR (%) | P value | FWBR (%) | P value | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Liver | Mesenteric veins | Total | Females | ||||||||
| Control | 8 | 0.6 (1.0) | 13.0 (3.0) | 13.9 (2.5) | 6.4 (2.5) | ||||||
| 5 | 4 | 0 | 0 | 0.8 (0.4) | 10.5 (5.2) | 11.3 (5.1) | 4.8 (2.2) | 18.9 | 0.3 | 25.5 | 0.35 |
| 6 | 3 | 0 | 0 | 0 (0) | 21.3 (12.5) | 21.3 (12.5) | 10.3 (6.1) | 0 | 0.92 | 0 | 0.84 |
| 7 | 6 | 2 | 0 | 0.5 (0.9) | 5.0 (3.5) | 5.5 (3.2) | 2.0 (1.9) | 60.4 | 0.01 | 68.6 | 0.01 |
| 8 | 4 | 0 | 0 | 1.0 (1.0) | 7.3 (4.5) | 8.3 (4.5) | 4.0 (2.9) | 40.5 | 0.03 | 37.3 | 0.2 |
| Control | 7 | 0.3 (0.8) | 24.9 (7.6) | 25.0 (8.1) | 12.3 (3.9) | ||||||
| 2 | 4 | 1 | 0 | 0.5 (0.5) | 11.5 (3.9) | 12.0 (6.0) | 5.5 (2.5) | 52.0 | 0.11 | 55.4 | 0.09 |
| 9 | 4 | 0 | 0 | 2.3 (0.8) | 1.0 (1.7) | 2.3 (0.8) | 1.0 (0.7) | 87.0 | 0.01 | 91.9 | 0.01 |
| Control | 6 | 1.3 (1.0) | 30.0 (3.9) | 31.3 (3.7) | 14.5 (3.5) | ||||||
| 1 | 3 | 0 | 0 | 1.0 (2.3) | 11.7 (6.2) | 13.0 (5.8) | 5.0 (1.7) | 58.5 | 0.02 | 58.6 | 0.02 |
| Control | 9 | 2.0 (3.5) | 27.0 (27.7) | 29.0 (28.5) | 17.8 (24.1) | ||||||
| 3 | 4 | 0 | 0 | 0.8 (1.5) | 16.0 (11.5) | 18.3 (10.9) | 7.8 (4.5) | 37.1 | 0.76 | 67.9 | 0.76 |
| MQ (data from reference 13) | 45.8 | 56.3 | |||||||||
| MQ (data from reference 14) | 64.0 | 77.6 | |||||||||
a
SD, standard deviation; TWR, total worm burden reduction; FWBR, female worm burden reduction; MQ, mefloquine.