Table 1.

Mycological efficacies of different concentrations of luliconazole cream and reference drugs in experimental tinea corporis in guinea pigs

Study and treatment group	Culture-positive rate (%)	Fungal burden score (mean ± SE)
Dose-response studye
Nontreated	100	10.0 ± 0.0
Cream base	100	9.5 ± 0.3
Luliconazole cream
0.02%	90	3.0 ± 0.7c
0.1%	60a,b	1.2 ± 0.4c,d
0.5%	0a,b	0c,d
1.0%	0a,b	0c,d
1.0% bifonazole cream	90	3.0 ± 1.0c
Short-term treatment studyf
Nontreated	100	10.0 ± 0.0
Cream base	100	9.9 ± 0.1
4-day treatment
1% luliconazole cream	20a,b	0.2 ± 0.1c,d
1% terbinafine cream	70	1.3 ± 0.3c
8-day treatment
1% luliconazole cream	0a,b	0c,d
1% terbinafine cream	60a	1.4 ± 0.5c
1% bifonazole cream	100	6.3 ± 0.4

^aP < 0.05 versus nontreated group, by Fisher's exact probability test (n = 10).

^bP < 0.05 versus cream base group, by Fisher's exact probability test (n = 10).

^cP < 0.05 versus nontreated group, by Steel's multiple-comparison rank sum test (n = 10).

^dP < 0.05 versus cream base group, by Steel's multiple-comparison rank sum test (n = 10).

^eTopical treatment was started on day 3 postinoculation and continued once daily for 7 consecutive days. The culture assay was performed on day 14 postinoculation.

^fTopical treatment was started on day 5 postinoculation and continued once daily for 4 or 8 consecutive days. The culture assay was performed on day 17 postinoculation.