Table 2.

Mycological efficacies of 1% luliconazole cream and reference drugs in experimental tinea pedis in guinea pigs^a

Study and treatment group	Culture-positive rate (%)	Fungal burden score (mean ± SE)
Short-term treatment study
7-day treatment
Nontreated	100	9.9 ± 0.1
1% luliconazole cream	0*	0#
1% terbinafine cream	62.5	1.5 ± 0.5#
1% bifonazole cream	100	6.3 ± 0.6
14-day treatment
Nontreated	100	10.0 ± 0.0
1% luliconazole cream	0*	0#
1% terbinafine cream	25	0.3 ± 0.2#
1% bifonazole cream	100	4.1 ± 1.0
Short-term treatment study using deactivator-supplemented medium
7-day treatment
Nontreated	100	10.0 ± 0.0
1.0% luliconazole cream	0*	0#
1.0% terbinafine cream	75	1.4 ± 0.6#
1.0% bifonazole cream	100	8.0 ± 0.7#
14-day treatment
Nontreated	100	9.5 ± 0.4
1.0% luliconazole cream	0*	0#
1.0% terbinafine cream	0*	0#
1.0% bifonazole cream	100	6.0 ± 0.9

^aDrug was applied topically once daily for 7 or 14 consecutive days. The culture assay was performed 14 days after the completion of the drug treatment, with or without a deactivator-supplemented medium. *, P < 0.05 versus nontreated group, by Fisher's exact probability test (n = 8); #, P < 0.05 versus nontreated group, by Steel's multiple-comparison rank sum test (n = 8).