Fig 2.

Locations of the PSI-7977-selected amino acid changes using JFH-1 NS5B (Protein Data Bank accession number 3I5K). The finger domain is colored blue, the thumb domain is colored green, and the palm domain is colored red. The two catalytic residues D220 and D318 are shown as sticks to show the proposed active site of RNA synthesis. The PSI-7977-selected amino acid changes (residues 179, 282, 289, 293, 434, and 479) are shown as spheres. The image on the right is a 90°C rotation of the image from the left to show the proximity of the mutations within finger and palm domains.