Table 1.
Baseline characteristics of study patients with moderate or severe renal insufficiency (CrCl, <50 ml/min) at study entry
| Characteristic | Value |
|
|---|---|---|
| Voriconazole (n = 41) | Amphotericin B/fluconazole (n = 17) | |
| Sex (male) (%) | 44 | 53 |
| Age (median, range) | 70 (18–90) | 71 (36–87) |
| APACHE II-score (median, range) | 15 (5–41) | 19 (7–29) |
| Surgical patient (%) | 46 | 53 |
| In ICU at baseline (%) | 54 | 41 |
| Mechanical ventilation (%) | 29 | 47 |
| Renal impairmenta | ||
| Moderate [no. (%)] | 32 (78) | 13 (76) |
| Severe [no. (%)] | 9 (22) | 4 (24) |
| Causative microorganism | ||
| C. albicans [no. (%)] | 17 (41) | 10 (58) |
| C. glabrata [no. (%)] | 5 (12) | 3 (18) |
| C. parapsilosis [no. (%)] | 6 (15) | 0 |
| C. tropicalis [no. (%)] | 8 (20) | 1 (6) |
| C. krusei [no. (%)] | 1 (2) | 0 |
| Mixed and other [no. (%)] | 4 (10) | 3 (18) |
a
Moderate renal impairment, baseline creatinine clearance of 30 to 50 ml/min; severe renal impairment, baseline creatinine clearance of <30ml/min