Fig 1.

Effects of rilpivirine on human preadipocytes differentiating in culture. Human preadipocytes were differentiated in culture in the presence of the indicated concentrations of drugs. (A) Representative microphotographs of adipocyte cell cultures differentiating in the presence of the indicated concentrations of drugs; (B) bars are means ± standard errors of the means (SEMs) (n = 4 or 5 replicates) of the extent of morphological adipocyte differentiation expressed relative to values from untreated control cells, defined as 100% (see Materials and Methods). *, P < 0.05; and **, P < 0.01 for each drug treatment versus control. #, P < 0.05 for rilpivirine versus efavirenz treatment at the same concentration. Duration of treatment was 15 days.