Table 2.
Pharmacokinetic profiles of ceftriaxone, ertapenem, meropenem, and doripenem against murine infections with Salmonella isolates S129-42 and S1-9210131
| Drug and dosage | S129-42 |
S1-9210131 |
||||||
|---|---|---|---|---|---|---|---|---|
| MIC (μg/ml) | Cmax/MIC | AUC/MIC | T> MIC | MIC (μg/ml) | Cmax/MIC | AUC/MIC | T> MIC | |
| Ceftriaxone, 100 mg/kg q12h | 0.062 | 4,354 | 7,070 | 60.8 | 12 | 22.5 | 36.5 | 17.4 |
| Meropenem, 50 mg/kg q6h | 0.031 | 868 | 1,454 | 50. | 0.031 | 868 | 1,454 | 50.1 |
| Doripenem, 50 mg/kg q6h | 0.062 | 469 | 1,064 | 36.1 | 0.25 | 116 | 264 | 25.0 |
| Ertapenem, 50 mg/kg q6h | <0.015 | >6,339 | >20,733 | >75.5 | <0.015 | >6,339 | >20,733 | >75.5 |