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. 2012 Apr 30;67(7):1683–1696. doi: 10.1093/jac/dks127

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© The Author 2012. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Antibacterial activity (MICs) of PBD-biaryl conjugates as determined using five staphylococcal and two enterococcal clinical isolates. Compounds eliciting MIC values of ≤4 mg/L for all seven Gram-positive bacteria were considered effective. The numbering system for the components of the compound library is shown in Table S1. PBD, pyrrolo(2,1-c)(1,4)benzodiazepine; Py, 1-methylpyrrol-3-amine; PyM, (1,5-dimethylpyrrol-2-yl)methanamine; Im, 1-methylimidazol-4-amine; In, 1-methylindol-5-amine; Bzf, benzofuran-5-amine; Bzt, benzothiophen-5-amine; BztMC, methyl 5-aminobenzothiophene-2-carboxylate; MPB, 4-(1-methyl-1H-pyrrol-3-yl)benzenamine; FB, 4-(3-furyl)benzenamine; TB, 4-(3-thienyl)benzenamine; MTaB, 3-(2-methylthiazol-4-yl)benzenamine; TdB, 4-(thiadiazol-4-yl)benzenamine; MB, 4-morpholinobenzenamine; MPpB, 4-(4-methylpiperazin-1-yl)benzenamine; MMB, 4-(morpholinomethyl)benzenamine; MEB, 4-(2-morpholinoethoxy)benzenamine; MEPM, [4-(2-morpholinoethoxy)phenyl]methanamine; MPA, 6-morpholinopyridin-3-amine.