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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Circ Cardiovasc Imaging. 2011 Aug 11;4(6):729–737. doi: 10.1161/CIRCIMAGING.111.966374

Figure 5.

Figure 5

Ability of Gd-TO to distinguish acutely necrotic myocardium. (A) The time course of Gd-TO accumulation was determined as the R1 of the infarcted myocardium. No uptake of the agent is seen 72–96 hours after infarction. (B) The uptake of Gd-TO can be well fitted using a three-compartment model in which cardiomyocytes move from a healthy to a necrotic state, and are then cleared. Each transition is governed by a different rate constant. A time delay of 18 hours from the initial injury to the onset of necrotic cell clearance produced the optimal fit. (C) R1 values for the uninjured septum, acutely infarcted mice injected with Gd-DTPA, and infarcted mice injected with Gd-TO are shown. Gd-TO uptake distinguished infarcts with evolution times of less than 48 hours from those with durations of greater than 72 hours (p < 0.001). Likewise, significant differences (p < 0.001) in myocardial R1 were seen between mice with acute infarcts (< 48 hours) injected with Gd-TO and those injected with Gd-DTPA. The accumulation of Gd-TO thus specifically identifies acutely necrotic cells.