Table 2. Percentage identity of the amino-acid sequences of selected metalloproteinases.
Protein (No. of residues) | Sequence identity† (%) | R.m.s. deviation (Å)/No. of Cα atoms |
---|---|---|
hADAM-8 (201) | 100 | — |
hADAM-33 (252) | 44 | 0.744/144 |
Adamalysin II (197) | 38 | 0.695/157 |
Atrolysin C (203) | 35 | 0.835/154 |
hADAMTS-1 (210) | 27 | 0.806/118 |
hADAMTS-4 (211) | 25 | 0.693/126 |
hADAMTS-5 (210) | 25 | 0.780/140 |
hADAM-17 (200) | 21 | 1.906/124 |
hMMP-12 (182) | 10 | ND‡ |
hMMP-13 (186) | 9 | ND‡ |
hMMP-8 (184) | 4 | ND‡ |
Sequence alignment was performed using ClustalW (Thompson et al., 2002 ▶).
No significant structural similarity was detected.