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Phylogenetic tree of human MHC (HLA) class II B genes and alleles. This tree was constructed by using Jukes–Cantor distances for the nucleotide sequences (564 bp) of exons 2 and 3 that encode the class II MHC β-chain domains β1 and β2, respectively. DMB is known to be distantly related to other B genes (Fig. 6).
