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Phylogenetic tree of 49 VH genes from various vertebrate species. This tree was constructed by using p-distances for the amino acid sequences of framework regions 1, 2, and 3. Most sequence data are from Ota and Nei (14), and additional sequences for cattle, sheep, pigs, and rabbits are from GenBank. The root of the tree was determined by using light chain genes as was done in ref. 14.
