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A potential mechanism for the facilitation of LTD by novelty. Manahan-Vaughan and Braunewell (1) report that exposing a rat to a novel environment produces a striking facilitation of homosynaptic LTD in vivo. Similar to the effect of novelty exposure, transient application of carbachol, an analogue of ACh, enables induction of LTD in visual cortex and hippocampus by synaptic stimulation that is normally without effect. This figure is modified, with permission, from ref. 20.
